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Evidence: Clinical study
Logical Profile #boswBoswellia / Indian Frankincense
Boswellia serrata
Mechanism of Action
"Direct non-redox allosteric inhibitor of 5-Lipoxygenase (5-LOX); prevents leukotriene B4 biosynthesis without causing gastric mucosal ulceration."
Active Compounds
Acetyl-11-keto-beta-boswellic acid (AKBA)
Beta-boswellic acid
Tissue Affinity
Colonic mucosa, Joint synovium, Bronchial epithelium
Medical Indications
Inflammatory bowel disease (Ulcerative Colitis, Crohn’s), osteoarthritis, asthma
Dosage Logic
Standardized extract enriched to >30% AKBA (ApresFlex / 5-Loxin) at 100-250mg daily with a lipid-containing meal.
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Drug Interactions
Minimal cytochrome interference; excellent GI tolerability.
Contraindications
Known hypersensitivity to frankincense oleoresin