Back to Library
Evidence: Clinical study
Logical Profile #milkMilk Thistle
Silybum marianum
Mechanism of Action
"Stabilizes hepatocyte cell membranes preventing toxin entry; promotes ribosomal RNA polymerase I protein synthesis and hepatic regeneration."
Active Compounds
Silybin A & B
Silicristin
Silidianin (Silymarin complex)
Tissue Affinity
Hepatocytes, Biliary canaliculi, Renal tubule cells
Medical Indications
Non-alcoholic fatty liver disease (NAFLD), toxic hepatitis, elevated AST/ALT
Dosage Logic
140-200mg standardized silymarin (80%) tid, preferably phospholipid-bound (Siliphos).
Safety Engine
Check if Milk Thistle is safe for your current medications and conditions.
NO PROFILE FOUND
Safety checks require an encrypted Health Mirror profile. No profile data is ever stored on our servers.
Create Health MirrorGeneral Cautions
Drug Interactions
Mild CYP2C9 inhibition; generally excellent safety profile.
Contraindications
Hormone-sensitive malignancies (caution due to mild estrogenic affinity)